​[link] Abstract Subjective memory complaints (SMCs) are early markers of cognitive decline. This systematic review, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, synthesizes the psychometric properties and clinical utility of the Subjective Memory Complaints Questionnaire (SMCQ) using data from 2009 to 2025. From 407 records, 163 studies were analyzed across categories including diagnostic accuracy, intervention outcomes, and pathological associations. The SMCQ demonstrated excellent internal consistency (Cronbach's α:

[link] A ​ bstract Background: Evidence regarding thyroid function changes with ageing remains inconsistent and the implications of potential changes are unclear. We aimed to investigate ageing-related thyroid function changes and their associations with mortality. Methods : In this individual participant data (IPD) analysis, prospective population-based cohorts were eligible for inclusion when data on thyroid function measurements and mortality were available in individuals aged 18 years and older. Eligible datasets were identified through a systematic search of PubMed.

[link] Abstract Gamma entrainment shows promise for Alzheimer’s disease (AD) treatment in preclinical models, but human trials have yielded heterogeneous results. We hypothesized that the clinical efficacy of gamma entrainment depends on individual neurophysiological receptivity, specifically the capacity for neural circuit plasticity. In this open-label pilot study, we screened 37 individuals and enrolled 16 participants with early AD (CDR 0.5–1.0, amyloid-positive) who completed 12 weeks of home-based flickering light stimulation at individually optimized gamma frequen

[link] Abstract Clozapine is the gold-standard treatment for treatment-resistant schizophrenia (TRS), yet its mechanism of action remains unclear. Previous studies implicated the caudate nucleus as a potential key region of clozapine-related structural changes. Texture analysis (TA), a quantitative image analysis technique that may sensitively capture subtle alterations of the underlying tissue microstructure, was utilized to investigate changes in the caudate following 18 weeks of clozapine treatment. Thirty-three patients with TRS initiated on clozapine and 31 first-li

[link] Abstract Aim : Distressing dreams were previously reported to predict future all-cause dementia among predominantly white US participants aged 79-89 years, particularly in men. We investigated whether disturbing dreams (nightmares and bad dreams) were associated with all-cause and Alzheimer dementia (AD) among individuals aged 60-89 years from diverse international regions. Methods : Data were from six longitudinal cohort studies across Brazil, China, France, Italy, South Korea, and Taiwan (n = 10,238, 42.5% men). Cox regressions with a random effect for study inv

[link] Abstract ​ Background To investigate whether amyloid-beta (Aβ) deposition in Alzheimer’s disease (AD) increases free water (FW) before cell loss, we examined regional Aβ levels, volume, and FW of the posterior cingulate cortex (PCC) and medial and inferior temporal cortex (MITC) across AD stages. Methods Aβ, volume, and FW in PCC and MITC were compared between normal cognition (NC), preclinical AD, prodromal AD, and dementia due to Alzheimer’s disease (DEMAD) groups. Multiple linear regression was used to analyze the effect of Aβ and volume on FW. Results Continuo

[link] Abstract ​ Background : Although most couples share a bed, current interventions rarely consider dyadic sleep patterns. Aims : We investigated whether bedtime alignment between partners affects longitudinal sleep outcomes in older couples, with particular attention to gender differences. Method : Based on the temporal relationship between partners' bedtimes and the earlier sleeper's sleep onset latency, 859 couples (1718 individuals) aged ≥60 years were classified into 5 mutually exclusive bedtime alignment groups. Pittsburgh Sleep Quality Index (PSQI) scores, sle

[link] Abstract ​ There is an abundance of high-quality clinical data and resources for Alzheimer's disease (AD) in Korea. To investigate therapeutic targets and biomarkers, and to progress the AD research field in Korea by standardizing the dementia dataset in Korea, the Trial Ready Registry (TRR) and Dementia Platform Korea (DPK) were developed. We designed the minimum common dataset (MCD) to collect data on patients with AD and human-derived materials, which consist of clinical data and positron emission tomography (PET) imaging, including both florbetaben (FBB)-PET a